Endings
The Epilogue and all 22 endings: which boss shows each one, and what your save needs first.
Epilogue (Mom)
endingPlays when you defeat Mom in Depths II.
Nothing to unlock first.
Sources:Endings
Ending 1 (Mom's Heart)
endingPlays the 1st time you defeat Mom's Heart in the Womb. Endings 1 to 11 come one per win, in order.
Needs The Womb
Sources:Endings
Ending 2 (Mom's Heart)
endingPlays the 2nd time you defeat Mom's Heart in the Womb. Endings 1 to 11 come one per win, in order.
Needs The Womb
Sources:Endings
Ending 3 (Mom's Heart)
endingPlays the 3rd time you defeat Mom's Heart in the Womb. Endings 1 to 11 come one per win, in order.
Needs The Womb
Sources:Endings
Ending 4 (Mom's Heart)
endingPlays the 4th time you defeat Mom's Heart in the Womb. Endings 1 to 11 come one per win, in order.
Needs The Womb
Sources:Endings
Ending 5 (Mom's Heart)
endingPlays the 5th time you defeat Mom's Heart in the Womb. Endings 1 to 11 come one per win, in order.
Needs The Womb
Sources:Endings
Ending 6 (Mom's Heart)
endingPlays the 6th time you defeat Mom's Heart in the Womb. Endings 1 to 11 come one per win, in order.
Needs The Womb
Sources:Endings
Ending 7 (Mom's Heart)
endingPlays the 7th time you defeat Mom's Heart in the Womb. Endings 1 to 11 come one per win, in order.
Needs The Womb
Sources:Endings
Ending 8 (Mom's Heart)
endingPlays the 8th time you defeat Mom's Heart in the Womb. Endings 1 to 11 come one per win, in order.
Needs The Womb
Sources:Endings
Ending 9 (Mom's Heart)
endingPlays the 9th time you defeat Mom's Heart in the Womb. Endings 1 to 11 come one per win, in order.
Needs The Womb
Sources:Endings
Ending 10 (Mom's Heart)
endingPlays the 10th time you defeat Mom's Heart in the Womb. Endings 1 to 11 come one per win, in order.
Needs The Womb
Sources:Endings
Ending 11 (Mom's Heart)
endingPlays the 11th time you defeat Mom's Heart in the Womb. Endings 1 to 11 come one per win, in order.
Needs The Womb
Sources:Endings
Ending 12 (Satan)
endingDefeat Satan at the end of Sheol.
Needs The Womb
Sources:Endings
Ending 13 (Isaac)
endingDefeat Isaac at the end of the Cathedral.
Needs The Womb
Sources:Endings
Ending 14 (???)
endingDefeat ??? at the end of the Chest.
Needs The Polaroid
Sources:Endings
Ending 15 (The Lamb)
endingDefeat The Lamb at the end of the Dark Room.
Needs The Negative
Sources:Endings
Ending 16 (Mega Satan)
endingDefeat Mega Satan behind the Golden Gate in the Chest or Dark Room.
Needs Angels
Sources:Endings
Ending 17 (Hush)
endingDefeat Hush in the Blue Womb for the first time.
Needs Blue Womb
Sources:Endings
Ending 18 (Ultra Greed)
endingDefeat Ultra Greed at the end of a Greed Mode run.
Nothing to unlock first.
Sources:Endings
Ending 19 (Ultra Greedier)
endingDefeat Ultra Greedier at the end of a Greedier run.
Needs Greedier!
Sources:Endings
Ending 20 (Delirium)
endingDefeat Delirium in The Void.
Needs New Area
Sources:Endings
Ending 21 (Mother)
endingDefeat Mother at the end of the Corpse.
Needs A Secret Exit
Sources:Endings
Ending 22 (The Beast)
endingDefeat Dogma and then The Beast in Home. This is the game's final ending.
Needs A Strange Door
Sources:Endings