Floors
Floors and areas the guides use, and what unlocks them.
??? (Blue Womb)
floorUnlocked by Blue Womb
Used in: A Secret Exit, Soul of Cain, New Area, Fart Baby, Purity, D12 and 67 more guides
Sources:??? (Floor)
Cathedral
floorNo unlock of its own. The guides below show how to reach it.
Used in: The Polaroid, Angels, Apollyon, I RULE!, BRAINS!, Backasswards and 92 more guides
No unlock condition stated, but the Blue Womb page mentions Cathedral/Sheol being 'not unlocked'.Sources:Cathedral??? (Floor)
Corpse II
floorUnlocked by A Secret Exit
Used in: A Strange Door, Jacob and Esau, Isaac's Awakening, Seeing Double, Meat Cleaver, Yuck Heart and 33 more guides
Sources:Corpse
Dark Room
floorChapter 6, reached from Sheol. Its boss is The Lamb. Unlocked by defeating Satan 5 times, the same condition as The Negative.
Unlocked by The Negative
Used in: The gate is open!, Angels, Apollyon, The Forgotten, Missing Poster, Gulp! (pill) and 78 more guides
Sources:Dark Room
Depths II
floorIncludes its Necropolis and Dank Depths variants.
No unlock of its own. The guides below show how to reach it.
Used in: The Womb, Red Key, Soul of Cain, Tainted Isaac, Tainted Magdalene, Tainted Cain and 93 more guides
Sources:Mom
Downpour II / Dross II
floorUnlocked by A Secret Exit
Used in: A Strange Door, Jacob and Esau, Isaac's Awakening, Seeing Double, Meat Cleaver, Yuck Heart and 34 more guides
Sources:Downpour
Home
floorUnlocked by A Strange Door
Used in: Red Key, Tainted Isaac, Tainted Magdalene, Tainted Cain, Tainted Judas, Tainted ??? and 46 more guides
Sources:Home
Mausoleum II / Gehenna II
floorUnlocked by A Secret Exit
Used in: A Strange Door, Jacob and Esau, Isaac's Awakening, Seeing Double, Meat Cleaver, Yuck Heart and 34 more guides
Sources:Mausoleum
Mines II / Ashpit II
floorUnlocked by A Secret Exit
Used in: A Strange Door, Jacob and Esau, Isaac's Awakening, Seeing Double, Meat Cleaver, Yuck Heart and 34 more guides
Sources:Mines
Sheol
floorNo unlock of its own. The guides below show how to reach it.
Used in: The Negative, The gate is open!, Angels, Judas, Apollyon, The Forgotten and 97 more guides
No unlock condition stated, but the Blue Womb page mentions Cathedral/Sheol being 'not unlocked'.Sources:Sheol??? (Floor)
The Chest
floorChapter 6, reached from the Cathedral. Its boss is ???.
No unlock of its own. The guides below show how to reach it.
Used in: Angels, Apollyon, I RULE!, Backasswards, Ultra Hard, The D20 and 71 more guides
No unlock condition is stated for the floor itself; the usual way in needs The Polaroid.Sources:Chest (Floor)
The Void
floorReached through a portal. Defeating Hush always opens one.
Unlocked by New Area
Used in: D infinity, Eucharist, Silver Dollar, Shade, King Baby, Bloody Crown and 31 more guides
Sources:The Void
Womb II
floorUtero is unlocked together with the Womb.
Unlocked by The Womb
Used in: Blue Womb, It Lives!, A Secret Exit, The Polaroid, The Negative, Soul of Cain and 249 more guides
Sources:Womb