Items
Items, trinkets and pickups that the guides use, and what unlocks them. Not every item in the game is listed: only the ones a guide needs.
Cracked Key
pickupUnlocked by Red Key
Used in: Tainted Isaac, Tainted Magdalene, Tainted Cain, Tainted Judas, Tainted ???, Tainted Eve and 11 more guides
Sources:Cracked Key
Dad's Note
itemNo unlock of its own. The guides below show how to reach it.
Used in: Red Key, Tainted Isaac, Tainted Magdalene, Tainted Cain, Tainted Judas, Tainted ??? and 46 more guides
Sources:Dad's Note
Gulp! (pill)
pickupUnlocked by Once More with Feeling!
Used in: Marbles
Sources:Pills
Key Piece 1
itemDropped by Uriel. With Key Piece 2 it forms the key to the Golden Gate.
Unlocked by Angels
Used in: Apollyon, Dad's Key, I RULE!, Backasswards, Ultra Hard, Cry Baby and 34 more guides
Sources:Key Piece 1Angel Room
Key Piece 2
itemDropped by Gabriel. With Key Piece 1 it forms the key to the Golden Gate.
Unlocked by Angels
Used in: Apollyon, Dad's Key, I RULE!, Backasswards, Ultra Hard, Cry Baby and 34 more guides
Sources:Key Piece 2Angel Room
Knife Piece 1
itemNo unlock of its own. The guides below show how to reach it.
Used in: A Strange Door, Jacob and Esau, Isaac's Awakening, Seeing Double, Meat Cleaver, Yuck Heart and 33 more guides
Sources:Knife Piece 1
Knife Piece 2
itemNo unlock of its own. The guides below show how to reach it.
Used in: A Strange Door, Jacob and Esau, Isaac's Awakening, Seeing Double, Meat Cleaver, Yuck Heart and 33 more guides
Sources:Knife Piece 2
Missing Poster
trinketUnlocked by Missing Poster
Used in: The Lost
Sources:Missing Poster
Red Key
itemUnlocked by Red Key
Sources:Red Key
Soul of Cain
pickupUnlocked by Soul of Cain
Used in: Red Key, Tainted Isaac, Tainted Magdalene, Tainted Cain, Tainted Judas, Tainted ??? and 84 more guides
Sources:Soul of Cain
The Negative
itemGuaranteed drop from Mom once unlocked. Taking it makes The Polaroid disappear.
Unlocked by The Negative
Used in: Red Key, The gate is open!, Angels, Tainted Isaac, Tainted Magdalene, Tainted Cain and 113 more guides
Sources:The Negative
The Polaroid
itemGuaranteed drop from Mom once unlocked. Taking it makes The Negative disappear.
Unlocked by The Polaroid
Used in: Red Key, Angels, Tainted Isaac, Tainted Magdalene, Tainted Cain, Tainted Judas and 123 more guides
Sources:The Polaroid