Lazarus
ReadyHave 4 or more soul hearts at the same time.
Achievement
Defeat Satan as Bethany, defeat Mom's Heart 11 times, and unlock Maggy's Faith.
In-game: “Unlocked challenge #38.”
Have 4 or more soul hearts at the same time.
Have 7 or more red heart containers at the same time.
Defeat Mom.
Reach Depths II and defeat Mom.
Sources:AchievementsWomb
Defeat Mom's Heart or It Lives! on Hard mode as Lazarus without dying.
After: Lazarus, The Womb
Defeat Mom's Heart 11 times.
After: The Womb
Defeat Satan 5 times.
After: The Womb
Defeat The Lamb as Magdalene.
After: Magdalene, The Womb, The Negative
Defeat Satan as Bethany.
After: Bethany, The Womb
Defeat Satan as Bethany, defeat Mom's Heart 11 times, and unlock Maggy's Faith.
After: Urn of Souls, It Lives!, Maggy's Faith