Lazarus
ReadyHave 4 or more soul hearts at the same time.
Achievement
Defeat ??? as Bethany.
In-game: “Complete the Chest with Bethany.”
Have 4 or more soul hearts at the same time.
Defeat Mom.
Reach Depths II and defeat Mom.
Sources:AchievementsWomb
Defeat Mom's Heart or It Lives! on Hard mode as Lazarus without dying.
After: Lazarus, The Womb
Defeat Isaac 5 times.
After: The Womb
Defeat ??? as Bethany.
After: Bethany, The Womb, The Polaroid