Samson
ReadyComplete 2 floors in a row without taking damage.
Achievement
Defeat Mega Satan as Tainted Samson.
Sources:AchievementsMega Satan
Complete 2 floors in a row without taking damage.
Defeat Mom.
Reach Depths II and defeat Mom.
Sources:AchievementsWomb
Defeat Mom's Heart 10 times.
After: The Womb
Defeat Isaac 5 times.
After: The Womb
Defeat Hush 3 times.
After: The Womb, Blue Womb
Complete Chapter 6 (defeat ??? in the Chest or The Lamb in the Dark Room).
After: The Womb, The Polaroid
Defeat Mother.
After: A Secret Exit
Open the hidden closet in Home as Samson.
After: Samson, The Polaroid, A Strange Door
Defeat Mega Satan as Tainted Samson.
After: The Savage, Angels, The Womb, The Polaroid