Cain
ReadyHold 55 coins at the same time.
Achievement
Defeat Isaac, ???, Satan and The Lamb as Tainted Cain.
Hold 55 coins at the same time.
Defeat Mom.
Reach Depths II and defeat Mom.
Sources:AchievementsWomb
Defeat Mom's Heart 10 times.
After: The Womb
Defeat Satan 5 times.
After: The Womb
Defeat Isaac 5 times.
After: The Womb
Defeat Hush 3 times.
After: The Womb, Blue Womb
Defeat Mother.
After: A Secret Exit
Open the hidden closet in Home as Cain.
After: Cain, The Polaroid, A Strange Door
Defeat Isaac, ???, Satan and The Lamb as Tainted Cain.
After: The Hoarder, The Womb, The Polaroid, The Negative