Lazarus
ReadyHave 4 or more soul hearts at the same time.
Achievement
Defeat Mega Satan as Bethany.
In-game: “Defeat Mega Satan with Bethany.”
Sources:AchievementsMega Satan
Have 4 or more soul hearts at the same time.
Defeat Mom.
Reach Depths II and defeat Mom.
Sources:AchievementsWomb
Defeat Mom's Heart or It Lives! on Hard mode as Lazarus without dying.
After: Lazarus, The Womb
Defeat Isaac 5 times.
After: The Womb
Complete Chapter 6 (defeat ??? in the Chest or The Lamb in the Dark Room).
After: The Womb, The Polaroid
Defeat Mega Satan as Bethany.
After: Bethany, Angels, The Womb, The Polaroid