Azazel
ReadyMake 3 deals with the Devil in one run.
Achievement
Defeat Mega Satan with every non-tainted character.
In-game: “Unlocked...”
Sources:AchievementsMega Satan
Make 3 deals with the Devil in one run.
Hold 55 coins at the same time.
Don't pick up any hearts for 2 floors in a row.
Donate 1000 coins to the Greed Donation Machine.
Have 4 or more soul hearts at the same time.
Have 7 or more red heart containers at the same time.
Complete 2 floors in a row without taking damage.
Defeat Mom.
Reach Depths II and defeat Mom.
Sources:AchievementsWomb
Defeat Mom's Heart 10 times.
After: The Womb
Defeat Mom's Heart or It Lives! on Hard mode as Lazarus without dying.
After: Lazarus, The Womb
Defeat Mom's Heart 10 times.
After: The Womb
Complete Chapter 4 (the Womb).
After: The Womb
Defeat Satan.
After: The Womb
Defeat Ultra Greed as Azazel.
After: Azazel
Defeat Satan 5 times.
After: The Womb
Defeat Isaac 5 times.
After: The Womb
Defeat Hush 3 times.
After: The Womb, Blue Womb
Complete Chapter 6 (defeat ??? in the Chest or The Lamb in the Dark Room).
After: The Womb, The Polaroid
Defeat The Lamb as Isaac.
After: The Womb, The Negative
Defeat The Lamb.
After: The Womb, The Negative
Defeat Mega Satan.
After: Angels, The Womb, The Polaroid
Defeat Mega Satan as Lilith.
After: Lilith, Angels, The Womb, The Polaroid
Defeat Mega Satan as Azazel.
After: Azazel, Angels, The Womb, The Polaroid
Defeat Mega Satan as ???.
After: ???, Angels, The Womb, The Polaroid
Defeat Mega Satan as Judas.
After: Judas, Angels, The Womb, The Polaroid
Defeat Mega Satan as Isaac.
After: Angels, The Womb, The Polaroid
Defeat Mega Satan as Bethany.
After: Bethany, Angels, The Womb, The Polaroid
Defeat Mega Satan as Cain.
After: Cain, Angels, The Womb, The Polaroid
Defeat Mother.
After: A Secret Exit
Defeat Mega Satan as Eve.
After: Eve, Angels, The Womb, The Polaroid
Defeat Mega Satan as Lazarus.
After: Lazarus, Angels, The Womb, The Polaroid
Defeat Mega Satan as Keeper.
After: Keeper, Angels, The Womb, The Polaroid
Defeat Mega Satan as Samson.
After: Samson, Angels, The Womb, The Polaroid
Defeat Mega Satan as Magdalene.
After: Magdalene, Angels, The Womb, The Polaroid
Dig up The Forgotten with Mom's Shovel in the Dark Room (a three-part process).
After: The gate is open!, The Womb, The Negative
Die in a Sacrifice Room while holding the Missing Poster.
After: Missing Poster
Defeat Mega Satan as Eden.
After: Eden, Angels, The Womb, The Polaroid
Defeat Mega Satan as The Forgotten.
After: The Forgotten, Angels, The Womb, The Polaroid
Defeat Mega Satan as Jacob and Esau.
After: Jacob and Esau, Angels, The Womb, The Polaroid
Defeat Mega Satan as Apollyon.
After: Apollyon, Angels, The Womb, The Polaroid
Defeat Mega Satan as The Lost.
After: The Lost, Angels, The Womb, The Polaroid
Defeat Mega Satan with every non-tainted character.
After: Cry Baby, Red Baby, Green Baby, Brown Baby, Blue Baby, Lil' Baby, Rage Baby, Black Baby, Long Baby, Yellow Baby, White Baby, Big Baby, Noose Baby, Mort Baby, Bound Baby, Glowing Baby, Illusion Baby