Cain
ReadyHold 55 coins at the same time.
Achievement
Earn every completion mark on Hard mode as Cain.
In-game: “Unlocked a new co-player baby.”
Sources:AchievementsCompletion Marks
Hold 55 coins at the same time.
Donate 500 coins to the Greed Donation Machine.
Defeat Mom.
Reach Depths II and defeat Mom.
Sources:AchievementsWomb
Defeat Satan as Cain.
After: Cain, The Womb
Defeat Isaac as Cain.
After: Cain, The Womb
Defeat Mom's Heart 10 times.
After: The Womb
Complete the Boss Rush as Cain.
After: Cain
Defeat Ultra Greed as Cain.
After: Cain
Defeat Mom's Heart or It Lives! on Hard mode as Cain.
After: Cain, The Womb
Defeat Ultra Greedier as Cain.
After: Greedier!, Cain
Defeat Satan 5 times.
After: The Womb
Defeat Isaac 5 times.
After: The Womb
Defeat Hush 3 times.
After: The Womb, Blue Womb
Defeat The Lamb as Cain.
After: Cain, The Womb, The Negative
Complete Chapter 6 (defeat ??? in the Chest or The Lamb in the Dark Room).
After: The Womb, The Polaroid
Defeat ??? as Cain.
After: Cain, The Womb, The Polaroid
Defeat Hush as Cain.
After: Cain, The Womb, Blue Womb
Defeat Hush.
After: The Womb, Blue Womb
Defeat Mother.
After: A Secret Exit
Defeat Mega Satan as Cain.
After: Cain, Angels, The Womb, The Polaroid
Defeat Mother as Cain.
After: Cain, A Secret Exit
Defeat Delirium as Cain.
After: Cain, The Womb, Blue Womb, New Area
Defeat The Beast as Cain.
After: Cain, The Polaroid, A Strange Door
Earn every completion mark on Hard mode as Cain.
After: A Bag of Pennies, A Bag of Bombs, Abel, Cain's Eye, Cain's Other Eye, Glass Baby, D12, Evil Eye, Green Baby, Silver Dollar, Sack of Sacks, Guppy's Eye, A Pound of Flesh, Cain