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Isaac Progression

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Unofficial fan project. Not affiliated with the developers of The Binding of Isaac.

Game facts are sourced from the Binding of Isaac Rebirth Wiki (CC BY-SA), and each guide links to its sources. Your progress is saved only in this browser.

Achievement

Serpent's Kiss

Defeat Satan as Lilith.

In-game: “Unlocked a new item.”

Sources:Achievements Sheol Satan

0 of 4 doneNext: Azazel

x

Stage 1any order

Azazel
Next up
Make 3 deals with the Devil in one run.
In a single run, take 3 deals from Devil Rooms.
Sources:Achievements Azazel
The Womb
Ready
Defeat Mom.

Stage 2

Lilith
Later
Defeat Ultra Greed as Azazel.
After: Azazel

Stage 3

Serpent's Kiss
Later
Defeat Satan as Lilith.
After: Lilith, The Womb