Samson
ReadyComplete 2 floors in a row without taking damage.
Achievement
Defeat Isaac, ???, Satan and The Lamb as Tainted Samson.
Complete 2 floors in a row without taking damage.
Defeat Mom.
Reach Depths II and defeat Mom.
Sources:AchievementsWomb
Defeat Mom's Heart 10 times.
After: The Womb
Defeat Satan 5 times.
After: The Womb
Defeat Isaac 5 times.
After: The Womb
Defeat Hush 3 times.
After: The Womb, Blue Womb
Defeat Mother.
After: A Secret Exit
Open the hidden closet in Home as Samson.
After: Samson, The Polaroid, A Strange Door
Defeat Isaac, ???, Satan and The Lamb as Tainted Samson.
After: The Savage, The Womb, The Polaroid, The Negative